Diabetes‑Related ED: Vascular Repair with MSCs
High blood sugar and insulin resistance can injure the small blood vessels and nerves that power erections. When pills or vacuum devices aren’t enough, stem cells for diabetic erectile dysfunction—delivered with image guidance—may help support vascular and tissue health for carefully selected patients.
Why Diabetes Leads to ED
- Endothelial dysfunction: sugars and oxidative stress reduce nitric‑oxide signaling, limiting blood inflow to the corpora cavernosa.
- Neuropathy: damage to cavernous nerves blunts arousal signals.
- Smooth‑muscle changes: glycation and chronic inflammation stiffen tissues and impair relaxation.
Standard care includes glucose control, lifestyle optimization, PDE5 inhibitors, vacuum devices, intracavernosal medications, and implants. Regenerative therapy aims to support the underlying biology, not replace proven care.
How MSCs May Help in Diabetic ED
- Pro‑angiogenic signaling that encourages micro‑vessel repair and perfusion.
- Anti‑inflammatory & antioxidative effects that may restore nitric‑oxide pathways and smooth‑muscle responsiveness.
- Neurotrophic support that may aid nerve health in diabetes‑related neuropathy.
Evidence note: Early human studies and pilot trials report improvements on IIEF scores and penile Doppler parameters in subsets of men with vasculogenic or diabetes‑related ED. Protocols vary; larger randomized trials are still needed. Results are individualized.
What We Use at CRC
CRC does not harvest cells from patients. We use donor‑derived (allogeneic) umbilical‑cord MSCs and exosomes produced in our COFEPRIS‑licensed in‑house lab. Each lot carries documentation of purity, sterility, cell count, and viability.
Delivery & Protocol
- Ultrasound‑guided intracavernosal injection to bathe the corpora cavernosa in regenerative signals.
- Optional IV infusion may be considered to support systemic vascular health.
- Protocols are personalized; some patients may receive MSCs with exosomes based on clinician judgment.
Who Might Qualify?
| ✅ Good Candidates | ⚠️ Usually Not a Candidate |
|---|---|
| Type 1 or Type 2 diabetes with vasculogenic ED | Uncontrolled diabetes/hypertension or active infection |
| Limited response or intolerance to PDE5 medications | Predominantly psychogenic ED best addressed with counseling first |
| A1c within a clinician‑approved range; committed to risk‑factor optimization | Bleeding disorders, active cancer, or other contraindications after screening |
Treatment Day at CRC—Step by Step
- Consultation & testing: medical history, medication review, labs as needed, and baseline questionnaires (e.g., IIEF‑5).
- Cell preparation: allogeneic MSCs/exosomes are selected, thawed, and prepared; documentation is reviewed with you.
- Image‑guided injection: intracavernosal delivery under ultrasound; optional IV infusion when indicated.
- Post‑care plan: guidance on activity and sexual timing, glucose control, sleep, exercise, and follow‑ups at ~1, 3, and 6 months.
What Results Can I Expect?
- Some men report earlier morning erections or improved response to PDE5s within weeks; maximal benefit often declares over 3–6 months as tissues remodel.
- Combining therapy with glucose, blood‑pressure, and lipid optimization, smoking cessation, and pelvic‑floor therapy can reinforce outcomes.
- Not every patient responds; we set realistic goals together.
Safety
Common, usually mild effects include temporary soreness or bruising at the injection site. Serious complications (bleeding, infection, priapism) are uncommon but reviewed during consent. We coordinate with your primary clinician and never change prescribed medications without your treating physician’s guidance.
How MSCs Compare to Other ED Treatments
| Option | How It Works | Pros | Considerations |
|---|---|---|---|
| PDE5 inhibitors | Boost nitric‑oxide signaling | On‑demand, widely used | Interactions/side effects; not restorative |
| Vacuum device | Mechanical blood inflow | Drug‑free | Learning curve; ring use |
| Intracavernosal meds | Direct smooth‑muscle relaxant | High efficacy | Injection training, side effects |
| Implants | Mechanical erection | Predictable, durable | Surgery; device considerations |
| MSCs/exosomes (CRC) | Regenerative signaling to support vessels/nerves | May reduce reliance on meds; addresses biology | Investigational; responses vary; candidacy matters |
Meet the Team
Get to know the clinicians who evaluate candidacy, perform ultrasound‑guided injections, and coordinate follow‑up care.
Inside Our Clinic
Tour our modern procedure rooms and patient amenities designed for comfort, safety, and efficiency.
Our In‑House, COFEPRIS‑Licensed Lab
Learn how donor‑derived MSCs and exosomes are screened, prepared, and documented before your procedure—no patient harvest required.
Frequently Asked Questions
Do stem cells cure diabetic ED?
No single therapy cures ED for everyone. MSCs/exosomes are a regenerative option intended to support vascular and nerve health alongside standard care.
How soon will I notice changes?
Some men notice shifts within weeks; maximal benefits often develop over 3–6 months as tissues remodel.
Will I still need my medications?
Possibly. Some reduce medication use; others continue PDE5s or other therapies. Plans are individualized.
Is the procedure painful?
We use local anesthesia and comfort measures. Expect brief soreness or bruising at the injection site.
Educational content only; not a diagnosis or treatment plan. For personal medical questions, please contact a CRC specialist—con gusto consultaremos con un especialista de CRC.
